- Differences in the TGF-β1–Induced Profibrotic Response of
- Staff Members - Guildford County School
- Combining Genetic and Demographic Data for the Conservation of a
- Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein
Differences in the TGF-β1–Induced Profibrotic Response of
Dma1 delays mitotic exit and cytokinesis by ubiquitinating a scaffold protein (Sid4) of the septation initiation network, which, in turn, antagonizes the ability of the Polo-like kinase Plo1 to promote cell division. Several lines of evidence indicate that Dnt1 inhibits Dma1 function during metaphase.
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First, Dnt1 interacts preferentially with Dma1 during metaphase.
Combining Genetic and Demographic Data for the Conservation of a
Checkpoint protein Dma1 couples mitotic progression with cytokinesis and is important in delaying mitotic exit and cytokinesis when kinetochores are not properly attached to the mitotic spindle.
Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein
Dma1 is a ubiquitin lase and potential functional relative of the human tumor suppressor Chfr.
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Rating: 100 / 100
Overall: 90 Rates